2012年2月5日 星期日

白藜芦醇对关节炎及类风湿的缓解作用

以膝关节为主的风湿性关节炎,发病率会高达85%,也就是说几乎所有的人都会在其一生中饱受关节疼痛的困扰。长期以来对于风湿性关节炎的治疗和预防的研究进展缓慢,但是却搞清楚了关节炎跟关节组织中的某些细胞因子(如TNF-α,LT-α等)的浓度过高有关。

当摄取白藜芦醇后,不管是已经有几十年膝关节炎还是几天前刚患的肩周炎,疼痛都会获得缓解。


这是为什么呢?这是因为白藜芦醇可以在短短几天内将血清中的炎症因子TNF-α,LT-α等的浓度降低到正常值。


而长期服用白藜芦醇,受损关节会得到全面康复,这跟白藜芦醇拥有抑制滑膜细胞异常增生(类风湿关节炎)、促进软骨细胞重新修复的能力有关,也就是说长期服用白藜芦醇是可以让受损关节得到全面修复的。



引用文献


  • Usha R, et al. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells. Arterioscler Thromb Vasc Biol 1999; 19: 419-426.
    http://atvb.ahajournals.org/cgi/reprint/19/2/419


  • Porath D, et al. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res. 2005; 49: 431-42.
    http://www3.interscience.wiley.com/journal/110431567/abstract


  • Elmali N, et al. Effects of Resveratrol in Inflammatory Arthritis. Inflammation 2007; 30: 1-6.
    http://atvb.ahajournals.org/cgi/content/abstract/19/2/419


  • Bertelli AA, et al. Resveratrol inhibits TNF alpha-induced endothelial cell activation. Therapie. 2001; 56: 613-616.
    http://www.ncbi.nlm.nih.gov/pubmed/11806302


  • Kowalski J, et al. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1βand tumor necrosis factor-α genes in J774.2 macrophages. Pharmcolog reports 2005; 57: 390-394.
    http://www.if-pan.krakow.pl/pjp/pdf/2005/3_390.pdf


  • Moon SK., et al. Resveratrol Suppresses Tumor Necrosis Factor-a-Induced Fractalkine Expression in Endothelial Cells. Mol Pharmacol 2006; 70:112–119.
    http://molpharm.aspetjournals.org/cgi/reprint/70/1/112



  • Doissy P, et al. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 2005; 65: 9943-9952.

  • http://cancerres.aacrjournals.org/cgi/reprint/65/21/9943


  • Elmali N, et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflammation Res. 2005; 54: 158-162.
    http://www.springerlink.com/content/m4v1600625172522/


  • Tang LL, et al. Inhibitory effect of resveratrol on the proliferation of synoviocytes in rheumatoid arthritis and its mechanism in vitro. J Cent South Univ(Med Sci)2006;31:528-533.
    http://xbyx.xysm.net/qikan/manage/wenzhang/200608528.pdf
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